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Article

The Arg16Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus.

Pharmacogenetics and genomics - 1 Apr 2008

Schouwenberg Bas J, Veldman Bart A, Spiering Wilko, Coenen Marieke J, Franke Barbara, Tack Cees J, de Galan Bastiaan E, Smits Paul

Abstract excerpt

Hypoglycemia unawareness has been linked to desensitization of the beta2-adrenergic receptor. Desensitization of the beta2-adrenergic receptor (ADRB2) is genetically determined by the Arg16Gly variant of this receptor. We tested the hypothesis that hypoglycemia unawareness is more common among patients homozygous for the Gly16 variant. We performed genotyping of the A265G (Arg16Gly) polymorphism in the ADRB2 gene...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

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Share to Diabetes Mellitus, Type 1

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Share to Polymorphism, Genetic

Share to Receptors, Adrenergic, beta-2

Source

Identifiers

PMID: 18334922
DOI: 10.1097/FPC.0b013e3282f70481

Genes

ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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