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Article

Impact of Genetic Polymorphism in the β2-Receptor Gene on Risk of Severe Hypoglycemia in Patients With Type 1 Diabetes.

The Journal of clinical endocrinology and metabolism - 1 Aug 2018

Rokamp Kim Zillo, Olsen Niels Vidiendal, Færch Louise, Kristensen Peter Lommer, Thorsteinsson Birger, Pedersen-Bjergaard Ulrik

Abstract excerpt

Context: Severe hypoglycemic events are unevenly distributed in people with type 1 diabetes, making a genetic influence probable. Of the common adrenoceptor β-2 receptor gene (ADRB2) polymorphisms, the Arg16 allele is associated with receptor downregulation and reduced agonist-mediated endogenous glucose production. Objective: We tested the hypothesis that the Arg16 variant is associated with severe hypoglycemia....

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Share to Aged
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Hypoglycemia

Share to Polymorphism, Genetic

Share to Receptors, Adrenergic, beta-2

Share to Risk Factors

Share to Severity of Illness Index

Source

Identifiers

PMID: 29757443
DOI: 10.1210/jc.2017-02739

Genes

ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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