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Article

PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host response.

Journal of virology - 1 Apr 2015

Hu Jiao, Mo Yiqun, Wang Xiaoquan, Gu Min, Hu Zenglei, Zhong Lei, Wu Qiwen, Hao Xiaoli, Hu Shunlin, Liu Wenbo, Liu Huimou, Liu Xiaowen, Liu Xiufan

Abstract excerpt

UNLABELLED: PA-X is a newly discovered protein that decreases the virulence of the 1918 H1N1 virus in a mouse model. However, the role of PA-X in the pathogenesis of highly pathogenic avian influenza viruses (HPAIV) of the H5N1 subtype in avian species is totally unknown. By generating two PA-X-deficient viruses and evaluating their virulence in different animal models, we show here that PA-X diminishes the...

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Identifiers

PMID: 25631083
DOI: 10.1128/JVI.02132-14
PMCID: PMC4442343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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