Article
UDP-glucuronosyltransferase 2B17 genotyping in Japanese athletes and evaluation of the current sports drug testing for detecting testosterone misuse.
Drug testing and analysis - 1 Mar 2013
Okano Masato, Ueda Toshihiko, Nishitani Yasunori, Kano Hiroko, Ikekita Ayako, Kageyama Shinji
Abstract excerpt
Ethnicity has been found to influence urinary testosterone glucuronide to epitestosterone glucuronide (T/E) ratios among athletes. Uridine diphospho-glucuronosyltransferase 2B17 (UGT2B17) is the most active enzyme in testosterone glucuronidation. UGT2B17 polymorphism analysis is rarely performed in Japanese athletes, and the influence of testosterone administration on steroid profiles and carbon isotope ratios,...
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