Article
Testosterone challenge and androgen receptor activity in relation to UGT2B17 genotypes.
European journal of clinical investigation - 1 Mar 2013
Ekström Lena, Cevenini Luca, Michelini Elisa, Schulze Jenny, Thörngren John-Olof, Belanger Alain, Guillemette Chantal, Garle Mats, Roda Aldo, Rane Anders
Abstract excerpt
BACKGROUND: We investigated the androgen receptor (AR) bioluminescense response in serum and urine before and after testosterone challenge in different genotypes of the UGT2B17 enzyme, which catalyses testosterone glucuronidation. MATERIAL AND METHODS: The androgen receptor activity was determined using a yeast-based bioluminescence assay. The androgens were analysed using LC-MS/MS, and the individuals were...
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