Article
A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice.
Developmental neurobiology - 1 May 2014
Harmacek Laura, Watkins-Chow Dawn E, Chen Jianfu, Jones Kenneth L, Pavan William J, Salbaum J Michael, Niswander Lee
Abstract excerpt
Failure of embryonic neural tube closure results in the second most common class of birth defects known as neural tube defects (NTDs). While NTDs are likely the result of complex multigenic dysfunction, it is not known whether polymorphisms in epigenetic regulators may be risk factors for NTDs. Here we characterized Baf155(msp3) , a unique ENU-induced allele in mice. Homozygous Baf155(mps3) embryos exhibit highly...
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