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Article

Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine.

Human mutation - 1 Apr 2008

Jarjanazi Hamdi, Kiefer Jeffrey, Savas Sevtap, Briollais Laurent, Tuzmen Sukru, Pabalan Noel, Ibrahim-Zada Irada, Mousses Spyro, Ozcelik Hilmi

Abstract excerpt

Chemotherapy is a major treatment modality for individuals affected by cancer. Currently, a number of genome-based technologies are being adopted to identify genes associated with drug response; however, large-scale genetic association applications are still limited. Here we describe a novel strategy based on the genetic and drug response data of the NCI60 cell lines to discover potential candidate genetic...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

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Source

Identifiers

PMID: 18330920
DOI: 10.1002/humu.20732

Genes

PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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