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Article

Using pharmacogene polymorphism panels to detect germline pharmacodynamic markers in oncology.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2014

Hertz Daniel L, McLeod Howard L

Abstract excerpt

The patient (germline) genome can influence the pharmacokinetics and pharmacodynamics of cancer therapy. The field of pharmacogenetics (PGx) has primarily focused on genetic predictors of pharmacokinetics, largely ignoring pharmacodynamics, using a candidate approach to assess single-nucleotide polymorphisms (SNP) with known relevance to drug pharmacokinetics such as enzymes and transporters. A more comprehensive...

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PMID: 24831276
DOI: 10.1158/1078-0432.CCR-13-2780

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