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Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: results from the German Investigation on Neurobiology in Alcoholism (GINA).

Alcohol (Fayetteville, N.Y.) - 1 Mar 2015

Semmler Alexander, Heese Peter, Stoffel-Wagner Birgit, Muschler Marc, Heberlein Annemarie, Bigler Laurent, Prost Jean-Christophe, Frieling Helge, Kornhuber Johannes, Banger Markus, Bleich Stefan, Hillemacher Thomas, Linnebank Michael

Abstract excerpt

Recent studies have shown that smoking and alcoholism may be associated with altered DNA methylation and that alcohol consumption might induce changes in DNA methylation by altering homocysteine metabolism. In this monocenter study, we included 363 consecutive patients referred for hospitalization for alcohol detoxification treatment. Blood samples were obtained on treatment days 1, 3, and 7 for measurement of...

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Identifiers

PMID: 25702197
DOI: 10.1016/j.alcohol.2015.01.004

Genes

CBS
DHFR
MTHFR
MTR
RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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