Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK4 IVS4-nt40G-->A and T2D-associated obesity in Italians.

Journal of cellular physiology - 1 Nov 2009

Meenakshisundaram Ramachandran, Gragnoli Claudia

Abstract excerpt

Cell cycle regulators play crucial roles in the preadipocyte proliferation and adipocyte differentiation. Cyclin-dependent kinase 4 (CDK4) mediates with D-type cyclins entry of cells into cell cycle in response to external stimuli. CDK4 plays a role in body weight, adipogenesis, and beta cell proliferation. CDK4 null mice develop type 2 diabetes (T2D). Furthermore, CDK4 variants are associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cyclin-Dependent Kinase 4
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to DNA Mutational Analysis

Share to Obesity

Share to White People

Source

Identifiers

PMID: 19634152
DOI: 10.1002/jcp.21874

Genes

CDK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK4 IVS4-nt40G-->A and T2D-associated obesity in Italians.PMID 19634152Read ↗

CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - a case-control study.Semantic proximity Read ↗

CDK4 IVS4-nt40G-->A SNP and type 2 diabetes in Italians.Semantic proximity Read ↗

MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes.Semantic proximity Read ↗

Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.Semantic proximity Read ↗

Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.Semantic proximity Read ↗

Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women.Semantic proximity Read ↗

TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition.Semantic proximity Read ↗

CHOP 5'UTR-c.279T>C and +nt30C>T variants are not associated with overweight condition or with tumors/cancer in Italians - a case-control study.Semantic proximity Read ↗

The TBC1D1 gene: structure, function, and association with obesity and related traits.Semantic proximity Read ↗

Cdkn2a deficiency promotes adipose tissue browningSemantic proximity Read ↗

Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits.Semantic proximity Read ↗

R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.