Article
Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2008
Tourne Sylvie, Maitre Blandine, Collmann Anthony, Layre Emilie, Mariotti Sabrina, Signorino-Gelo François, Loch Caroline, Salamero Jean, Gilleron Martine, Angénieux Catherine, Cazenave Jean-Pierre, Mori Lucia, Hanau Daniel, Puzo Germain, De Libero Gennaro, de la Salle Henri
Abstract excerpt
The human CD1a-d proteins are plasma membrane molecules involved in the presentation of lipid Ags to T cells. In contrast, CD1e is an intracellular protein present in a soluble form in late endosomes or lysosomes and is essential for the processing of complex glycolipid Ags such as hexamannosylated phosphatidyl-myo-inositol, PIM(6). CD1e is formed by the association of beta(2)-microglobulin with an alpha-chain...
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