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Article

5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients.

Psychiatry research - 15 May 2009

Kato Masaki, Zanardi Raffaella, Rossini David, De Ronchi Diana, Okugawa Gaku, Kinoshita Toshihiko, Colombo Cristina, Serretti Alessandro

Abstract excerpt

The 5-HT2A receptor is a key modulator of the serotonin pathway. We previously observed a marginal association between 5-HT2A gene variants and antidepressant efficacy in Japanese and Italian population but in the opposite direction. In the present report, we hypothesize that discrepant findings on 5-HT2A gene variants could be due to both the effect of ethnicity and a possible specific effect on some symptom...

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Source

Identifiers

PMID: 19361869
DOI: 10.1016/j.psychres.2007.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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