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Article

Alpha-synuclein, pesticides, and Parkinson disease: a case-control study.

Neurology - 15 Apr 2008

Brighina L, Frigerio R, Schneider N K, Lesnick T G, de Andrade M, Cunningham J M, Farrer M J, Lincoln S J, Checkoway H, Rocca W A, Maraganore D M

Abstract excerpt

BACKGROUND: Aggregation and fibrillization of the alpha-synuclein protein (encoded by the SNCA gene) may represent key events in the pathogenesis of Parkinson disease (PD). Variability in the length of a dinucleotide repeat sequence (REP1) within the SNCA promoter confers susceptibility to sporadic PD. Pesticide exposures may also confer susceptibility to PD. Our objective was to test possible joint effects of...

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Source

Identifiers

PMID: 18322262
DOI: 10.1212/01.wnl.0000304049.31377.f2

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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