Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The in vivo rate of somatic adenomatous polyposis coli mutation.

The American journal of pathology - 1 Apr 2008

Hornsby Chris, Page Karen M, Tomlinson Ian

Abstract excerpt

Cancer arises through successive somatic mutations/epimutations of oncogenes and tumor-suppressor genes. Accurate estimates of the rates at which these (epi)mutations occur are a vital but missing link in our emerging quantitative understanding of tumorigenesis. Their absence has hindered argumen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Adenomatous Polyposis Coli
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Age Distribution

Share to Cell Lineage

Share to Epithelium

Share to Mutation

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 18321998
DOI: 10.2353/ajpath.2008.070724
PMCID: PMC2276411

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18321998-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The in vivo rate of somatic adenomatous polyposis coli mutation.PMID 18321998Read ↗

The earliest stages of neoplastic transformation in Familial Adenomatous PolyposisSemantic proximity Read ↗

Genotype-phenotype correlations at the adenomatous polyposis coli (APC) gene.Semantic proximity Read ↗

The APC gene in colorectal cancer.Semantic proximity Read ↗

The onset and extent of genomic instability in sporadic colorectal tumor progressionSemantic proximity Read ↗

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.Semantic proximity Read ↗

Mathematical Modeling Quantifies "Just-Right" APC Inactivation for Colorectal Cancer Initiation.Semantic proximity Read ↗

Role of heterozygous APC mutation in niche succession and initiation of colorectal cancer--a computational study.Semantic proximity Read ↗

Mechanisms of APC-driven tumorigenesis: lessons from mouse models.Semantic proximity Read ↗

Quantifying ‘just-right’ APC inactivation for colorectal cancer initiationSemantic proximity Read ↗

Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.Semantic proximity Read ↗

Origin of Somatic Mutations in β-Catenin versus Adenomatous Polyposis Coli in Colon Cancer: Random Mutagenesis in Animal Models versus Nonrandom Mutagenesis in Humans.Semantic proximity Read ↗

Biology of the adenomatous polyposis coli tumor suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.