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Article

The in vivo rate of somatic adenomatous polyposis coli mutation.

The American journal of pathology - 1 Apr 2008

Hornsby Chris, Page Karen M, Tomlinson Ian

Abstract excerpt

Cancer arises through successive somatic mutations/epimutations of oncogenes and tumor-suppressor genes. Accurate estimates of the rates at which these (epi)mutations occur are a vital but missing link in our emerging quantitative understanding of tumorigenesis. Their absence has hindered arguments concerning the importance of genetic instability in tumorigenesis and the number of mutations that precede malignant...

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Identifiers

PMID: 18321998
DOI: 10.2353/ajpath.2008.070724
PMCID: PMC2276411

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APC
FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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