Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale.

Bioinformatics (Oxford, England) - 30 Jun 2023

Mendelevich Asia, Gupta Saumya, Pakharev Aleksei, Teodosiadis Athanasios, Mironov Andrey A, Gimelbrant Alexander A

Abstract excerpt

MOTIVATION: Analysis of allele-specific expression is strongly affected by the technical noise present in RNA-seq experiments. Previously, we showed that technical replicates can be used for precise estimates of this noise, and we provided a tool for correction of technical noise in allele-specific expression analysis. This approach is very accurate but costly due to the need for two or more replicates of each...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Library

Source

Open in PubMed Open full text

Identifiers

PMID: 37387154
DOI: 10.1093/bioinformatics/btad254
PMCID: PMC10311301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale.PMID 37387154Read ↗

Foreign RNA spike-ins enable accurate allele-specific expression analysis at scaleSemantic proximity Read ↗

Normalization of human RNA-seq experiments using chimpanzee RNA as a spike-in standard.Semantic proximity Read ↗

The effect of background noise and its removal on the analysis of single-cell expression data.Semantic proximity Read ↗

Synthesizing human-specific spike-in standards for RNA-seq experiments and assessing their technical performanceSemantic proximity Read ↗

Transcriptome Universal Single-isoform COntrol: A Framework for Evaluating Transcriptome reconstruction QualitySemantic proximity Read ↗

Evaluating Methods for Differential Gene Expression And Alternative Splicing Using Internal Synthetic ControlsSemantic proximity Read ↗

CellTag Indexing: genetic barcode-based sample multiplexing for single-cell genomicsSemantic proximity Read ↗

Beyond library size: a field guide to NGS normalizationSemantic proximity Read ↗

Replicate sequencing libraries are important for quantification of allelic imbalance.Semantic proximity Read ↗

A novel statistical approach for jointly analyzing RNA-Seq data from F1 reciprocal crosses and inbred lines.Semantic proximity Read ↗

Allele-specific detection of single mRNA molecules in situ.Semantic proximity Read ↗

Quantitative comparison of single-cell RNA sequencing versus single-molecule RNA imaging for quantifying transcriptional noiseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.