Article
Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice.
Proceedings of the National Academy of Sciences of the United States of America - 11 Mar 2008
Wadsworth Jonathan D F, Joiner Susan, Linehan Jacqueline M, Desbruslais Melanie, Fox Katie, Cooper Sharon, Cronier Sabrina, Asante Emmanuel A, Mead Simon, Brandner Sebastian, Hill Andrew F, Collinge John
Abstract excerpt
Kuru provides our principal experience of an epidemic human prion disease and primarily affected the Fore linguistic group of the Eastern Highlands of Papua New Guinea. Kuru was transmitted by the practice of consuming dead relatives as a mark of respect and mourning (transumption). To date, detailed information of the prion strain type propagated in kuru has been lacking. Here, we directly compare the...
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