Article
Genetics of human prion disease.
Developments in biological standardization - 1 Jan 1993
Ridley R M, Baker H F
Abstract excerpt
Prion diseases are fatal neurodegenerative disorders in which an abnormal isoform of prion protein (PrPSc) accumulates in brain. Prion disease is either inherited as an autosomal dominant disorder with very high penetrance, sporadic, where no epidemiological association with other human or animal...
Topics
- Adult
- Age of Onset
- Aged
- Alleles
- Codon
- Genes, Dominant
- Genetic Variation
- Humans
- Iatrogenic Disease
- Middle Aged
- Mutation
- PrPSc Proteins
- Prion Diseases
- Prions