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Article

Different Motifs Regulate Trafficking of SorCS1 Isoforms

27 Feb 2008

Abstract excerpt

The type I transmembrane protein SorCS1 is a member of the Vps10p-domain receptor family comprised of Sortilin, SorLA and SorCS1, -2 and -3. Current information indicates that Sortilin and SorLA mediate intracellular protein trafficking and sorting, but little is known about the cellular functions of the SorCS subgroup. SorCS1 binds platelet-derived growth factor-BB (PDGF-BB) and is expressed in isoforms...

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PMID: 18315530
DOI: 10.1111/j.1600-0854.2008.00731.x

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