Article
Regulation of apoptotic and growth inhibitory activities of C/EBPalpha in different cell lines.
Experimental cell research - 15 Apr 2008
Wang Guo-Li, Shi Xiurong, Salisbury Elizabeth, Timchenko Nikolai A
Abstract excerpt
C/EBPalpha is expressed in many tissues and inhibits cell growth. In this paper, we have examined mechanisms which regulate activities of C/EBPalpha in cell lines derived from different tissues. We found that C/EBPalpha possesses strong pro-apoptotic activity in NIH3T3 cells, while this activity is not detected in 3T3-L1, Hep3B2 and HEK293 cells. Micro-array data show that C/EBPalpha activates many genes of...
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