Article
Putative association of the single nucleotide polymorphisms in RASSF1A promoter with Korean lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2008
Sung Jae Sook, Han Sle Gi Lo, Whang Young Mi, Shin Eun Soon, Lee Jae Won, Lee Hyo Jung, Ryu Jeong-Seon, Choi In Keun, Park Kyong Hwa, Kim Jun Suk, Shin Sang Won, Chu Elizabeth K, Kim Yeul Hong
Abstract excerpt
SUMMARY: The RASSF1 gene, a putative tumor suppressor gene located on human chromosome 3p21, has attracted a great deal of attention because of frequent allelic loss and gene silencing via promoter hypermethylation in a variety of human malignancies. To evaluate the role of RASSF1A gene in lung cancer risk, genotypes of the RASSF1A promoter region (-710 C>T and -392T>C) were determined in 410 lung cancer patients...
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