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An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia

21 Aug 2008

Abstract excerpt

Patients with cytogenetically normal acute myeloid leukemia (CN-AML) show heterogeneous treatment outcomes. We used gene-expression profiling to develop a gene signature that predicts overall survival (OS) in CN-AML. Based on data from 163 patients treated in the German AMLCG 1999 trial and analyzed on oligonucleotide microarrays, we used supervised principal component analysis to identify 86 probe sets...

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PMID: 18716133
DOI: 10.1182/blood-2008-02-134411

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