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Article

Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy.

Trends in molecular medicine - 1 Feb 2001

Walton R, Johnstone E, Munafò M, Neville M, Griffiths S

Abstract excerpt

The molecular processes that underlie addiction are beginning to unfold. Genetically determined variations in dopaminergic neurotransmission predispose to nicotine dependence. In addition, tobacco use is likely to be governed by the rate at which smokers metabolize nicotine. Functional polymorphisms in CYTOCHROME P450 monooxygenases that metabolize nicotine have now been defined and it should soon be possible to...

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PMID: 11286758
DOI: 10.1016/s1471-4914(01)01915-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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