Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

2 Aug 2012

Abstract excerpt

Severe acute respiratory syndrome (SARS) coronavirus (SCoV) is an enveloped virus containing a single-stranded, positive-sense RNA genome. Nine mRNAs carrying a set of common 5' and 3' untranslated regions (UTR) are synthesized from the incoming viral genomic RNA in cells infected with SCoV. A nonstructural SCoV nsp1 protein causes a severe translational shutoff by binding to the 40S ribosomal subunits. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22855488
DOI: 10.1128/jvi.01700-12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNAPMID 22855488Read ↗

Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradationSemantic proximity Read ↗

Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene ExpressionSemantic proximity Read ↗

The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translationSemantic proximity Read ↗

Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral responseSemantic proximity Read ↗

An evolutionarily conserved strategy for ribosome binding and inhibition by β-coronavirus non-structural protein 1Semantic proximity Read ↗

SARS-CoV-2 NSP1 induces mRNA cleavages on the ribosomeSemantic proximity Read ↗

The Endonucleolytic RNA Cleavage Function of nsp1 of Middle East Respiratory Syndrome Coronavirus Promotes the Production of Infectious Virus Particles in Specific Human Cell LinesSemantic proximity Read ↗

I(nsp1)ecting SARS-CoV-2–ribosome interactionsSemantic proximity Read ↗

Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells.Semantic proximity Read ↗

Parsing the role of NSP1 in SARS-CoV-2 infectionSemantic proximity Read ↗

Viral and cellular translation during SARS‐CoV‐2 infectionSemantic proximity Read ↗

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation InitiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.