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Article

Amyloid precursor protein increases cortical neuron size in transgenic mice.

Neurobiology of aging - 1 Aug 2009

Oh Esther S, Savonenko Alena V, King Julie F, Fangmark Tucker Stina M, Rudow Gay L, Xu Guilian, Borchelt David R, Troncoso Juan C

Abstract excerpt

The amyloid precursor protein (APP) is the source of beta-amyloid, a pivotal peptide in the pathogenesis of Alzheimer's disease (AD). This study examines the possible effect of APP transgene expression on neuronal size by measuring the volumes of cortical neurons (microm(3)) in transgenic mouse m...

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Identifiers

PMID: 18304698
DOI: 10.1016/j.neurobiolaging.2007.12.024
PMCID: PMC2796369

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18304698-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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