Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis.

doi:10.1186/1471-2407-9-303

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Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis.

BMC cancer - 27 Aug 2009

Scartozzi Mario, Bearzi Italo, Mandolesi Alessandra, Pierantoni Chiara, Loupakis Fotios, Zaniboni Alberto, Negri Francesca, Quadri Antonello, Zorzi Fausto, Galizia Eva, Berardi Rossana, Biscotti Tommasina, Labianca Roberto, Masi Gianluca, Falcone Alfredo, Cascinu Stefano

Abstract excerpt

BACKGROUND: K-RAS wild type colorectal tumors show an improved response rate to anti-EGFR monoclonal antibodies. Nevertheless 70% to 40% of these patients still does not seem to benefit from this therapeutic approach. FISH EGFR GCN has been previously demonstrated to correlate with clinical outcome of colorectal cancer treated with anti-EGFR monoclonal antibodies. CISH also seemed able to provide accurate EGFR...

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PMID: 19712476
DOI: 10.1186/1471-2407-9-303
PMCID: PMC3087339

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EGFR
CISH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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