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Article

Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.

PloS one - 1 Jan 2009

Gandhi Jeet, Zhang Jianling, Xie Yang, Soh Junichi, Shigematsu Hisayuki, Zhang Wei, Yamamoto Hiromasa, Peyton Michael, Girard Luc, Lockwood William W, Lam Wan L, Varella-Garcia Marileila, Minna John D, Gazdar Adi F

Abstract excerpt

BACKGROUND: Deregulation of EGFR signaling is common in non-small cell lung cancers (NSCLC) and this finding led to the development of tyrosine kinase inhibitors (TKIs) that are highly effective in a subset of NSCLC. Mutations of EGFR (mEGFR) and copy number gains (CNGs) of EGFR (gEGFR) and HER2 (gHER2) have been reported to predict for TKI response. Mutations in KRAS (mKRAS) are associated with primary...

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PMID: 19238210
DOI: 10.1371/journal.pone.0004576
PMCID: PMC2642732

Genes

EGFR
KRAS
BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.PMID 19238210Read ↗

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