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Article

Molecular population genetics of PCSK9: a signature of recent positive selection.

Pharmacogenetics and genomics - 1 Mar 2008

Ding Keyue, Kullo Iftikhar J

Abstract excerpt

OBJECTIVE: Proprotein convertase subtilisin-like kexin type 9 (PCSK9) is a newly discovered serine protease that plays a key role in regulating plasma low density lipoprotein (LDL) cholesterol levels. Both rare mutations and common variants in the coding regions of PCSK9 affect LDL cholesterol levels and coronary heart disease risk, as well as response to lipid-lowering therapy. METHODS: The authors characterized...

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Source

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Identifiers

PMID: 18300938
DOI: 10.1097/FPC.0b013e3282f44d99
PMCID: PMC2842919

Genes

PCSK9
FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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