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Article

Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer's disease risk.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jun 2008

Combarros O, Sánchez-Juan P, Riancho J A, Mateo I, Rodríguez-Rodríguez E, Infante J, García-Gorostiaga I, Vázquez-Higuera J L, Berciano J

Abstract excerpt

A chronic inflammatory process with activation of microglial cells contribute to the neurodegeneration associated with Alzheimer's disease (AD). Estrogen could protect the brain from neurodegeneration by augmenting the secretion of the anti-inflammatory interleukin (IL)-10 from microglial cells. In a case-control study in 231 AD patients and 194 healthy controls, we examined whether the combined effects between...

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PMID: 18299793
DOI: 10.1007/s00702-008-0028-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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