Article
Identification of a novel BRCA2 and CHEK2 A-C-G-C haplotype in Turkish patients affected with breast cancer.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Haytural Hazal, Yalcinkaya Nazli, Akan Gokce, Arikan Soykan, Ozkok Elif, Cakmakoglu Bedia, Yaylim Ilhan, Aydin Makbule, Atalar Fatmahan
Abstract excerpt
BACKGROUND: Many breast cancers are caused by certain rare and familial mutations in the high or moderate penetrance genes BRCA1, BRCA2 and CHEK2. The aim of this study was to examine the allele and genotype frequencies of seven mutations in BRCA1, BRCA2 and CHEK2 genes in breast cancer patients and to investigate their isolated and combined associations with breast cancer risk. METHODS: We genotyped seven...
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