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Article

Linkage disequilibrium based genotype calling from low-coverage shotgun sequencing reads.

BMC bioinformatics - 15 Feb 2011

Duitama Jorge, Kennedy Justin, Dinakar Sanjiv, Hernández Yözen, Wu Yufeng, Măndoiu Ion I

Abstract excerpt

BACKGROUND: Recent technology advances have enabled sequencing of individual genomes, promising to revolutionize biomedical research. However, deep sequencing remains more expensive than microarrays for performing whole-genome SNP genotyping. RESULTS: In this paper we introduce a new multi-locus statistical model and computationally efficient genotype calling algorithms that integrate shotgun sequencing data with...

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PMID: 21342586
DOI: 10.1186/1471-2105-12-S1-S53
PMCID: PMC3044311

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