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Article

Is Inhibitor of differentiation 3 involved in human primary Sjögren's syndrome?

Rheumatology (Oxford, England) - 1 Apr 2008

Sellam J, Miceli-Richard C, Gottenberg J-E, Proust A, Ittah M, Lavie F, Loiseau P, Mariette X

Abstract excerpt

OBJECTIVES: Inhibitor of differentiation 3 (Id3)-deficient mice show sicca symptoms, lymphocyte infiltration of exocrine glands and positive anti-Ro/SSA and anti-La/SSB antibodies, all hallmarks of primary Sjögren's syndrome (pSS). The impairment of Id3 in T cells and, possibly, in salivary glandular epithelial cells (SGECs) seems to be involved. This animal model prompted us to investigate the role of Id3 in...

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PMID: 18296721
DOI: 10.1093/rheumatology/ken013

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SSB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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