Article
Impaired ribosome biogenesis disrupts the integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus.
Eukaryotic cell - 1 Apr 2008
Bhabhra Ruchi, Richie Daryl L, Kim H Stanley, Nierman William C, Fortwendel Jarrod, Aris John P, Rhodes Judith C, Askew David S
Abstract excerpt
Aspergillus fumigatus is an important opportunistic fungal pathogen that is responsible for high mortality rates in the immunosuppressed population. CgrA, the A. fumigatus ortholog of a Saccharomyces cerevisiae nucleolar protein involved in ribosome biogenesis, contributes to the virulence of this fungus by supporting rapid growth at 37 degrees C. To determine how CgrA affects ribosome biogenesis in A. fumigatus,...
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