Article
Impaired Bioenergetics in Mutant Mitochondrial DNA Determines Cell Fate During Seizure-Like Activity.
Molecular neurobiology - 1 Jan 2019
Kovac Stjepana, Preza Elisavet, Houlden Henry, Walker Matthew C, Abramov Andrey Y
Abstract excerpt
Mutations in genes affecting mitochondrial proteins are increasingly recognised in patients with epilepsy, but the factors determining cell fate during seizure activity in these mutations remain unknown. Fluorescent dye imaging techniques were applied to fibroblast cell lines from patients suffering from common mitochondrial mutations and to age-matched controls. Using live cell imaging techniques in fibroblasts,...
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