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Article

Mutations of the mitochondrial genome: clinical overview and possible pathophysiology of cell damage.

Biochemical Society symposium - 1 Jan 1999

Rothman S M

Abstract excerpt

Mitochondria possess their own DNA and transcription and translation machinery for the synthesis of 13 protein subunits for the oxidative phosphorylation system, two rRNAs and 22 tRNAs. In 1988 the first human neurodegenerative diseases associated with mutations in the mitochondrial genome were described. The most recent biochemical and genetic research suggests that mitochondrial disorders are best categorized...

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Identifiers

PMID: 10989662
DOI: 10.1042/bss0660111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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