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Article

Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology?

American journal of physiology. Cell physiology - 1 Jul 2007

Koopman Werner J H, Verkaart Sjoerd, Visch Henk Jan, van Emst-de Vries Sjenet, Nijtmans Leo G J, Smeitink Jan A M, Willems Peter H G M

Abstract excerpt

Malfunction of NADH:ubiquinone oxidoreductase or complex I (CI), the first and largest complex of the mitochondrial oxidative phosphorylation system, has been implicated in a wide variety of human disorders. To demonstrate a quantitative relationship between CI amount and activity and mitochondrial shape and cellular reactive oxygen species (ROS) levels, we recently combined native electrophoresis and confocal...

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PMID: 17428841
DOI: 10.1152/ajpcell.00194.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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