Article
Organization of the human synphilin-1 gene, a candidate for Parkinson's disease.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2000
Engelender S, Wanner T, Kleiderlein J J, Wakabayashi K, Tsuji S, Takahashi H, Ashworth R, Margolis R L, Ross C A
Abstract excerpt
We have recently identified a protein we called synphilin-1, which interacts in vivo with alpha-synuclein. Mutations in alpha-synuclein cause familial Parkinson's disease (PD). Alpha-synuclein protein is present in the pathologic lesions of familial and sporadic PD, and diffuse Lewy body disease, indicating an important pathogenic role for alpha-synuclein. Here we describe the structure of the human synphilin-1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.