Article

C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100A8 and S100A9

2021-12-09

Abstract excerpt

<h4>SUMMARY</h4> The proinflammatory alarmins S100A8 and S100A9 are among the most abundant proteins in neutrophils and monocytes but completely silenced after differentiation to macrophages. The molecular mechanisms of the extraordinarily dynamic transcriptional regulation of s100a8 and s100a9 genes, however, are only barely understood. Using an unbiased genome-wide CRISPR/Cas9 knockout based screening approac...

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Literature Corpus work: 974b844e-0815-5076-9da7-d95cbbae1ff4
DOI: 10.1101/2021.12.05.471309

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