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Article

Requirement of TCF7L2 for TGF-beta-dependent transcriptional activation of the TMEPAI gene.

The Journal of biological chemistry - 3 Dec 2010

Nakano Naoko, Itoh Susumu, Watanabe Yukihide, Maeyama Kota, Itoh Fumiko, Kato Mitsuyasu

Abstract excerpt

The TGF-β and Wnt pathways are involved in cell fate and tumorigenicity. A recent report indicated that a TGF-β target gene, TMEPAI (transmembrane prostate androgen-induced RNA), is possibly also a downstream target of Wnt signaling. Although TMEPAI was believed to be involved in tumorigenicity because of its blockage of TGF-β signaling, how TGF-β and Wnt signals affect the activation of the TMEPAI gene is not...

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Identifiers

PMID: 20889500
DOI: 10.1074/jbc.M110.132209
PMCID: PMC2992236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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