Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ets Gene PEA3 Cooperates with β-Catenin-Lef-1 and c-Jun in Regulation of Osteopontin Transcription

1 May 2004

Abstract excerpt

Osteopontin (OPN) is a multifunctional protein implicated in mammary development, neoplastic change, and metastasis. OPN is a target gene for beta-catenin-T cell factor signaling, which is commonly disturbed during mammary oncogenesis, but the understanding of OPN regulation is incomplete. Data base-assisted bioinformatic analysis of the OPN promoter region has revealed the presence of T cell factor-, Ets-, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to dental development and anomalies
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14990565
DOI: 10.1074/jbc.m311131200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ets Gene PEA3 Cooperates with β-Catenin-Lef-1 and c-Jun in Regulation of Osteopontin TranscriptionPMID 14990565Read ↗

Polyomavirus enhancer activator 3 protein promotes breast cancer metastatic progression through Snail‐induced epithelial–mesenchymal transitionSemantic proximity Read ↗

HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancerSemantic proximity Read ↗

Osteopontin induces multiple changes in gene expression that reflect the six “hallmarks of cancer” in a model of breast cancer progressionSemantic proximity Read ↗

PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinomaSemantic proximity Read ↗

Expression of PEA3/E1AF/ETV4, an Ets-related transcription factor, in breast tumors: positive links to MMP2, NRG1 and CGB expressionSemantic proximity Read ↗

The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinomaSemantic proximity Read ↗

Changes in the Expression of Many Ets Family Transcription Factors and of Potential Target Genes in Normal Mammary Tissue and TumorsSemantic proximity Read ↗

The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development.Semantic proximity Read ↗

Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.Semantic proximity Read ↗

PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells.Semantic proximity Read ↗

Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β–SMAD3 pathway in non-small cell lung adenocarcinomaSemantic proximity Read ↗

The Role of LEF/TCF Factors in Neoplastic TransformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.