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Article

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.

The EMBO journal - 19 Mar 2008

Yamanaka Tomoyuki, Miyazaki Haruko, Oyama Fumitaka, Kurosawa Masaru, Washizu Chika, Doi Hiroshi, Nukina Nobuyuki

Abstract excerpt

In Huntington's disease (HD), mutant Huntingtin, which contains expanded polyglutamine stretches, forms nuclear aggregates in neurons. The interactions of several transcriptional factors with mutant Huntingtin, as well as altered expression of many genes in HD models, imply the involvement of tra...

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Identifiers

PMID: 18288205
DOI: 10.1038/emboj.2008.23
PMCID: PMC2274932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18288205-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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