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Article

Induction of chemokines, MCP-1, and KC in the mutant huntingtin expressing neuronal cells because of proteasomal dysfunction.

Journal of neurochemistry - 1 Feb 2009

Godavarthi Swetha K, Narender Doronala, Mishra Amit, Goswami Anand, Rao Sudheendra N R, Nukina Nobuyuki, Jana Nihar Ranjan

Abstract excerpt

Huntington's disease is a hereditary neurodegenerative disorder caused by an aberrant polyglutamine expansion in the amino terminus of the huntingtin protein. The resultant mutant huntingtin form aggregates in neurons and causes neuronal dysfunction and degeneration in many ways including transcriptional dysregulation. Here, we report that the expression of mutant huntingtin in the mouse neuroblastoma cell...

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PMID: 19187096
DOI: 10.1111/j.1471-4159.2008.05823.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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