Article
Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons.
PloS one - 1 Jan 2013
Klenke Christin, Widera Darius, Engelen Thomas, Müller Janine, Noll Thomas, Niehaus Karsten, Schmitz M Lienhard, Kaltschmidt Barbara, Kaltschmidt Christian
Abstract excerpt
Signaling via NF-κB in neurons depends on complex formation with interactors such as dynein/dynactin motor complex and can be triggered by synaptic activation. However, so far a detailed interaction map for the neuronal NF-κB is missing. In this study we used mass spectrometry to identify novel interactors of NF-κB p65 within the brain. Hsc70 was identified as a novel neuronal interactor of NF-κB p65. In HEK293...
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