A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis.

doi:10.1002/ijc.25420

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Article

A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis.

International journal of cancer - 15 Mar 2011

Nieters Alexandra, Bracci Paige M, de Sanjosé Silvia, Becker Nikolaus, Maynadié Marc, Benavente Yolanda, Foretova Lenka, Cocco Pierluigi, Staines Anthony, Holly Elizabeth A, Boffetta Paolo, Brennan Paul, Skibola Christine F

Abstract excerpt

Interaction between CD40 and its ligand, CD154, has a key function in immune regulation. Recent experimental data support a role of deregulated CD40 signalling in lymphomagenesis. Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma. Here, the association of this variant with...

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PMID: 20473910
DOI: 10.1002/ijc.25420
PMCID: PMC3876741

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