Article
Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2008
Ignat Mihaela, Teletin Marius, Tisserand Johan, Khetchoumian Konstantin, Dennefeld Christine, Chambon Pierre, Losson Régine, Mark Manuel
Abstract excerpt
Calcification of arteries is a major risk factor for cardiovascular mortality in humans. Using genetic approaches, we demonstrate here that the transcriptional intermediary factor 1alpha (TIF1alpha), recently shown to function as a tumor suppressor in murine hepatocytes, also participates in a molecular cascade that prevents calcifications in arterioles and medium-sized arteries. We further provide genetic...
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