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Article

A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Blood - 1 May 2008

French Deborah, Hamilton Leo H, Mattano Leonard A, Sather Harland N, Devidas Meenakshi, Nachman James B, Relling Mary V

Abstract excerpt

As glucocorticoid use increased in acute lymphoblastic leukemia, osteonecrosis became an increasingly frequent complication. Besides increased age, host risk factors are poorly defined. We tested whether 12 polymorphisms were associated with osteonecrosis among patients 10 years and older treated on the CCG1882 protocol. Candidate genes (TYMS, MTHFR, ABCB1, BGLAP, ACP5, LRP5, ESR1, PAI-1, VDR, PTH, and PTHR) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Plasminogen Activator Inhibitor 1

Share to Polymorphism, Genetic

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

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Identifiers

PMID: 18285546
DOI: 10.1182/blood-2007-11-123885
PMCID: PMC2343589

Genes

ABCB1
ACP5
BGLAP
ESR1
LRP5
MTHFR
PTH
SERPINE1
TYMS
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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