Article
Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain.
Molecular and cellular biology - 1 May 2008
Laoukili Jamila, Alvarez Monica, Meijer Lars A T, Stahl Marie, Mohammed Shabaz, Kleij Livio, Heck Albert J R, Medema René H
Abstract excerpt
The Forkhead transcription factor FoxM1 is an important regulator of gene expression during the G(2) phase. Here, we show that FoxM1 transcriptional activity is kept low during G(1)/S through the action of its N-terminal autoinhibitory domain. We found that cyclin A/cdk complexes are required to...
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