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Article

Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction.

PLoS genetics - 1 Jul 2016

Gelino Sara, Chang Jessica T, Kumsta Caroline, She Xingyu, Davis Andrew, Nguyen Christian, Panowski Siler, Hansen Malene

Abstract excerpt

Dietary restriction (DR) is a dietary regimen that extends lifespan in many organisms. One mechanism contributing to the conserved effect of DR on longevity is the cellular recycling process autophagy, which is induced in response to nutrient scarcity and increases sequestration of cytosolic material into double-membrane autophagosomes for degradation in the lysosome. Although autophagy plays a direct role in...

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PMID: 27414651
DOI: 10.1371/journal.pgen.1006135
PMCID: PMC4945006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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