Article
A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K+ channels responsible for the IA currents in cerebellum granular cells.
Biochimica et biophysica acta - 1 Apr 2008
Romeo Stefania, Corzo Gerardo, Vasile Attilio, Satake Honoo, Prestipino Gianfranco, Possani Lourival D
Abstract excerpt
Discrepin is a scorpion peptide that blocks preferentially the IA currents of the voltage-dependent K+ channel of rat cerebellum granular cells. It was isolated from the venom of the buthid scorpion Tityus discrepans and contains 38 amino acid residues with a pyroglutamic acid at the N-terminal site. Discrepin has the lowest sequence identity (approx. 50%) among the six members of the alpha-KTx15 sub-family of...
Topics
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Cerebellum
- Dose-Response Relationship, Drug
- Membrane Potentials
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Patch-Clamp Techniques
- Potassium Channel Blockers
- Potassium Channels, Voltage-Gated