Article
Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes.
Clinical & experimental ophthalmology - 1 Mar 2008
Petrovic Mojca Globocnik, Krkovic Miha, Osredkar Josko, Hawlina Marko, Petrovic Daniel
Abstract excerpt
BACKGROUND: Basic fibroblast growth factor (bFGF) expression is implicated in proliferative diabetic retinopathy (PDR). The aim of this study was to investigate the association of genetic polymorphisms (-553T/A, -834T/A and -921C/G) in the promoter region of the bFGF gene with PDR in patients with type 2 diabetes. The second aim was to determine whether serum levels of bFGF are affected by genetic factors....
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