Article
An association between vascular endothelial growth factor gene promoter polymorphisms and diabetic retinopathy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Jan 2008
Szaflik Jacek P, Wysocki Tomasz, Kowalski Michal, Majsterek Ireneusz, Borucka Anna I, Blasiak Janusz, Szaflik Jerzy
Abstract excerpt
BACKGROUND: Diabetic retinopathy is a highly prevalent cause of visual loss in Western countries. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor implicated in the development of the proliferative stage of this disease. Reports have suggested that polymorphisms at positions -460 and -634 of the 5' untranslated region of the VEGF gene increase its basal promoter activity. METHODS: To...
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